How cells respond to DNA damage
Barbara Bachtler
Press and Public Relations
Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
10/20/2010 13: 33
it comes to damage the genetic material (DNA) repair enzymes and gene switches are activated, which decide the fate of the affected cells. Researchers at the Max Delbrück Center (MDC) Berlin-Buch now show how the gene regulator NF-kappaB, which coordinates a cellular survival program is activated by DNA damage. Dr. Michael Hinz, Dr. Michael Mann style and Prof. Dr. Claus Scheidereit describe a dual signal path, allowing the transmission of signals. NF-kappaB is associated with the resistance of cancer cells to radiotherapy and chemotherapy in combination, exert their effects by DNA damage (Molecular Cell, DOI 10.1016/j.molcel.2010.09.008) *.
The human genetic material is daily threatened by UV radiation, chemicals or toxic metabolites. In order to prevent permanent damage to the genetic material, human cells have concerning control systems, DNA damage within seconds identify and fix quickly. Next ........ .. How cells respond to DNA damage There is relationship between hair color and pain tolerance, at the back leading to endorphins (body's own painkillers)
POMC-related receptors, and possibly hormones. Shall be required with dental treatment For example, more stunning. Electrically induced pain is more tolerable, however. If animals this gene variant, based on melanin have, they are obviously at risk particularly from sunlight, radiation, nuclear power plants. The inappropriate dose makes the poison. In Chernobyl proves that animals with partially or completely yellow, reddish, brownish fur, feathers as particularly at risk for damage to the human sind.Bei Genvarante be up to 100-fold greater risk of cancer, as in general population.
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